Royal Air Force Typhoon FGR4s have operated alongside France's air force in a joint strike on an hidden munitions depot in Syria operated by the Daesh militant organization, according to the British defence ministry.
The location, located using surveillance, was thought to be storing arms and explosives, the statement said, and was situated in mountainous terrain just north of the ancient city of Palmyra in Syria's central region.
"Our aircraft employed laser-guided Paveway IV weapons to hit a several access tunnels leading to the site... early reports indicate the strike was effective," officials stated.
There was no indication of any harm to civilians in the attack late on Saturday and every plane involved returned to base without incident, the MoD added.
The British jets were backed up by a Voyager tanker plane.
The Islamic State group - alternatively referred to as the so-called Islamic State - established extremist governance over large swathes of both Syria and Iraq prior to its 2019 collapse.
"This operation demonstrates our UK leadership, and commitment to operate in unison with allied nations, to eradicate any revival of the terrorist group and their dangerous and violent ideologies in the area," the British Defence Secretary the Defence Secretary stated.
British military aircraft have performed surveillance missions over Syria to "deter any attempted resurgence" of the group after its routing at the battle of Baghuz in the year 2019, the authorities noted.
"I must thank the personnel of the UK armed forces involved in this strike for their professionalism and their courage," the Defence Secretary added. "Including them were a great many British troops deployed over the festive period. This action, to take out militants who threaten our way of life, demonstrates how British military are ready to step up, throughout the year, keeping Britain secure within its borders and powerful internationally."
In December, the American forces conducted what it called a "large-scale strike" on Daesh sites in Syria, following an attack claimed the lives of two US servicemembers and a civilian interpreter in the Palmyra area.
The United Nations reports Daesh still boasts an estimated 5,000 to 7,000 fighters in Syria and Iraq.